| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM50153973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302864 |
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| Ki | 75±n/a nM |
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| Citation |  Garaj V; Puccetti L; Fasolis G; Winum JY; Montero JL; Scozzafava A; Vullo D; Innocenti A; Supuran CT Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg Med Chem Lett 14:5427-33 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase |
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| Synonyms: | CA-I | CAB | Carbonate dehydratase I | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM50153973 |
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| n/a |
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| Name | BDBM50153973 |
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| Synonyms: | 4-[2-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-ethyl]-benzenesulfonamide | CHEMBL187274 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H11Cl2N5O2S |
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| Mol. Mass. | 348.208 |
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| SMILES | NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(Cl)n2)cc1 |
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| Structure | 
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