| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
|---|
| Ligand | BDBM50156525 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_306030 (CHEMBL829956) |
|---|
| IC50 | 64±n/a nM |
|---|
| Citation |  Wang, M; Winneroski, LL; Ardecky, RJ; Babine, RE; Brooks, DA; Etgen, GJ; Hutchison, DR; Kauffman, RF; Kunkel, A; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, MK; Rito, CJ; Rungta, DK; Tripp, AE; Wilson, SB; Xu, Y; Zink, RW; McCarthy, JR Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis. Bioorg Med Chem Lett14:6113-6 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Peroxisome proliferator-activated receptor alpha |
|---|
| Name: | Peroxisome proliferator-activated receptor alpha |
|---|
| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 52222.08 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07869 |
|---|
| Residue: | 468 |
|---|
| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
|
|
|
|---|
| BDBM50156525 |
|---|
| n/a |
|---|
| Name | BDBM50156525 |
|---|
| Synonyms: | 2-Methyl-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-2-p-tolyloxy-propionic acid | CHEMBL366138 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H29NO5 |
|---|
| Mol. Mass. | 471.5443 |
|---|
| SMILES | Cc1oc(nc1CCOc1ccc(CC(C)(Oc2ccc(C)cc2)C(O)=O)cc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
