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TargetProthrombin
LigandBDBM50292189
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302401 (CHEMBL829646)
Ki 0.08±n/a nM
Citation Nantermet, PGBurgey, CSRobinson, KAPellicore, JMNewton, CLDeng, JZSelnick, HGLewis, SDLucas, BJKrueger, JAMiller-Stein, CWhite, RBWong, BMcMasters, DRWallace, AALynch, JJYan, YChen, ZKuo, LGardell, SJShafer, JAVacca, JPLyle, TA P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold. Bioorg Med Chem Lett15:2771-5 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prothrombin
Name:Prothrombin
Synonyms:Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:Protein
Mol. Mass.:70029.57
Organism:Homo sapiens (Human)
Description:P00734
Residue:622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50292189
n/a
NameBDBM50292189
Synonyms:2-[2-(3-Chloro-benzylamino)-2-hydroxy-ethyl]-6-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-1-oxy-nicotinonitrile | CHEMBL195960
TypeSmall organic molecule
Emp. Form.C22H20ClF2N5O2
Mol. Mass.459.876
SMILESOC(Cc1c(ccc(NCC(F)(F)c2ccccn2)[n+]1[O-])C#N)NCc1cccc(Cl)c1
Structure
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