| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostacyclin receptor |
|---|
| Ligand | BDBM50167890 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_302783 (CHEMBL839468) |
|---|
| Ki | 12±n/a nM |
|---|
| Citation |  Hattori, K; Okitsu, O; Tabuchi, S; Taniguchi, K; Nishio, M; Koyama, S; Seki, J; Sakane, K Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2. Bioorg Med Chem Lett15:3279-83 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostacyclin receptor |
|---|
| Name: | Prostacyclin receptor |
|---|
| Synonyms: | PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 40968.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The membranes prepared from human platelet were used in binding assay. |
|---|
| Residue: | 386 |
|---|
| Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
|
|
|
|---|
| BDBM50167890 |
|---|
| n/a |
|---|
| Name | BDBM50167890 |
|---|
| Synonyms: | CHEMBL190497 | FR-193262 | Sodium; {(R)-5-[(R)-2-(4,5-diphenyl-oxazol-2-yl)-pyrrolidin-1-yl]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H29N2O4 |
|---|
| Mol. Mass. | 493.5735 |
|---|
| SMILES | [O-]C(=O)COc1cccc2[C@@H](CCCc12)N1CCC[C@@H]1c1nc(c(o1)-c1ccccc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
