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TargetCarbonic anhydrase 2
LigandBDBM50171019
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302944
Ki 159±n/a nM
Citation Mincione FStarnotti MMasini EBacciottini LScrivanti CCasini AVullo DScozzafava ASupuran CT Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett 15:3821-7 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrases; II & IX
Synonyms:CA-II | CA2 | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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  Blast E-value cutoff:
BDBM50171019
n/a
NameBDBM50171019
Synonyms:4-{2-[({2-[4-(aminosulfonyl)phenyl]ethyl}amino)carbonothioyl]hydrazino}benzoic acid | CHEMBL180195
TypeSmall organic molecule
Emp. Form.C16H18N4O4S2
Mol. Mass.394.469
SMILESNS(=O)(=O)c1ccc(CCNC(=S)NNc2ccc(cc2)C(O)=O)cc1
Structure
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