| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 8 |
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| Ligand | BDBM50004051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306301 (CHEMBL828593) |
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| IC50 | 5.1±n/a nM |
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| Citation |  Wheeler, WJ; Clodfelter, DK; Collado, I; Kulanthaivel, P; Pedregal, C; Stoddard, EA; Wright, RA; Schoepp, DD (2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors. Bioorg Med Chem Lett15:349-51 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 8 |
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| Name: | Metabotropic glutamate receptor 8 |
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| Synonyms: | GPRC1H | GRM8 | GRM8_HUMAN | MGLUR8 | Metabotropic glutamate receptor 8 | metabotropic glutamate 8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 101759.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 8 GRM8 HUMAN::O00222 |
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| Residue: | 908 |
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| Sequence: | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
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| BDBM50004051 |
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| n/a |
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| Name | BDBM50004051 |
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| Synonyms: | 2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosphono-butyric acid (AP4) | 4-Amino Phosphonobutyrate | CHEMBL285843 | GlcN-6-P synthase inhibitor, 1 (racemic mixture) | L-AP4 |
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| Type | Small organic molecule |
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| Emp. Form. | C4H10NO5P |
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| Mol. Mass. | 183.0997 |
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| SMILES | NC(CCP(O)(O)=O)C(O)=O |
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| Structure | 
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