| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
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| Ligand | BDBM50159758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302796 (CHEMBL839480) |
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| Ki | 9±n/a nM |
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| Citation |  Belley, M; Gallant, M; Roy, B; Houde, K; Lachance, N; Labelle, M; Trimble, LA; Chauret, N; Li, C; Sawyer, N; Tremblay, N; Lamontagne, S; Carrière, MC; Denis, D; Greig, GM; Slipetz, D; Metters, KM; Gordon, R; Chan, CC; Zamboni, RJ Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists. Bioorg Med Chem Lett15:527-30 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP3 subtype |
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| Name: | Prostaglandin E2 receptor EP3 subtype |
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| Synonyms: | PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 43335.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43115 |
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| Residue: | 390 |
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| Sequence: | MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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| BDBM50159758 |
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| n/a |
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| Name | BDBM50159758 |
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| Synonyms: | 3-(2-{(E)-3-[2-(2,6-Dichloro-benzyloxy)-3-methyl-phenyl]-3-hydroxy-propenyl}-phenyl)-acrylic acid | CHEMBL360290 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22Cl2O4 |
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| Mol. Mass. | 469.356 |
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| SMILES | Cc1cccc(C(O)\C=C\c2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl |
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| Structure | 
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