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TargetProstaglandin E2 receptor EP1 subtype
LigandBDBM50159778
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302794 (CHEMBL839478)
Ki 6700±n/a nM
Citation Belley, MGallant, MRoy, BHoude, KLachance, NLabelle, MTrimble, LAChauret, NLi, CSawyer, NTremblay, NLamontagne, SCarrière, MCDenis, DGreig, GMSlipetz, DMetters, KMGordon, RChan, CCZamboni, RJ Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists. Bioorg Med Chem Lett15:527-30 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP1 subtype
Name:Prostaglandin E2 receptor EP1 subtype
Synonyms:PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:Enzyme
Mol. Mass.:41834.57
Organism:Homo sapiens (Human)
Description:P34995
Residue:402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA
AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF
GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE
LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR
PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV
GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR
QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50159778
n/a
NameBDBM50159778
Synonyms:(E)-3-(2-{(E)-3-[2-(2,6-Dichloro-benzyloxy)-3-methyl-phenyl]-allyl}-phenyl)-acrylic acid | CHEMBL183919
TypeSmall organic molecule
Emp. Form.C26H22Cl2O3
Mol. Mass.453.357
SMILESCc1cccc(\C=C\Cc2ccccc2\C=C\C(O)=O)c1OCc1c(Cl)cccc1Cl
Structure
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