Ki Summary

Reaction Details

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Target

Reverse transcriptase/RNaseH

Ligand

BDBM50160555

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_306023 (CHEMBL833538)

IC50

3280±n/a nM

Citation

Summerer, D; Marx, A 4'C-ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase. Bioorg Med Chem Lett15:869-71 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Reverse transcriptase/RNaseH

Name:

Reverse transcriptase/RNaseH

Synonyms:

HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH

Type:

PROTEIN

Mol. Mass.:

65229.15

Organism:

Human immunodeficiency virus 1

Description:

ChEMBL_1473730

Residue:

566

Sequence:

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID

BDBM50160555

n/a

Name

BDBM50160555

Synonyms:

[(2R,3S,5R)-2-ethynyl-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl tetrahydrogen triphosphate

Type

Small organic molecule

Emp. Form.

C12H13N2O14P3

Mol. Mass.

502.1601

SMILES

Cc1cn([C@H]2C[C@H](O)[C@@](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)(O2)C#C)c(=O)[nH]c1=O

Structure