Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM10874 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302410 (CHEMBL828815) |
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Ki | 3.7±n/a nM |
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Citation | Vullo, D; Innocenti, A; Nishimori, I; Pastorek, J; Scozzafava, A; Pastoreková, S; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs? Bioorg Med Chem Lett15:963-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM10874 |
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n/a |
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Name | BDBM10874 |
Synonyms: | 6-hydroxy-1,3-benzothiazole-2-sulfonamide | CHEMBL6685 | aromatic/heteroaromatic sulfonamide 19 |
Type | Small organic molecule |
Emp. Form. | C7H6N2O3S2 |
Mol. Mass. | 230.264 |
SMILES | NS(=O)(=O)c1nc2ccc(O)cc2s1 |
Structure |
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