| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
|---|
| Ligand | BDBM50165116 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305877 (CHEMBL831921) |
|---|
| IC50 | >400000±n/a nM |
|---|
| Citation |  Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg Med Chem Lett15:2177-80 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Eukaryotic translation initiation factor 4E |
|---|
| Name: | Eukaryotic translation initiation factor 4E |
|---|
| Synonyms: | EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25095.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06730 |
|---|
| Residue: | 217 |
|---|
| Sequence: | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
|
|
|
|---|
| BDBM50165116 |
|---|
| n/a |
|---|
| Name | BDBM50165116 |
|---|
| Synonyms: | CHEMBL194007 | tetrasodium ({[(2R,3R,5R)-5-(2-amino-6-hydroxy-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphonato}oxy)(phosphonatooxy)phosphinate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12N5O13P3 |
|---|
| Mol. Mass. | 503.1515 |
|---|
| SMILES | Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O1 |
|---|
| Structure | 
|
|---|
Search and Browse
