Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50154213 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303501 (CHEMBL839973) |
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Ki | 672±n/a nM |
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Citation | Grundt, P; Williams, IA; Lewis, JW; Husbands, SM Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore. J Med Chem47:5069-75 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50154213 |
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n/a |
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Name | BDBM50154213 |
Synonyms: | 7-(diallylamino)-8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol | CHEMBL364133 |
Type | Small organic molecule |
Emp. Form. | C18H25NO |
Mol. Mass. | 271.3972 |
SMILES | CC1(C)C(CCc2ccc(O)cc12)N(CC=C)CC=C |
Structure |
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