Reaction Details |
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Target | MO15-related protein kinase Pfmrk |
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Ligand | BDBM5718 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_306159 (CHEMBL832347) |
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IC50 | 1100000±n/a nM |
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Citation | Bhattacharjee, AK; Geyer, JA; Woodard, CL; Kathcart, AK; Nichols, DA; Prigge, ST; Li, Z; Mott, BT; Waters, NC A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem47:5418-26 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MO15-related protein kinase Pfmrk |
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Name: | MO15-related protein kinase Pfmrk |
Synonyms: | Protein kinase Pfmrk |
Type: | PROTEIN |
Mol. Mass.: | 37992.30 |
Organism: | Plasmodium falciparum |
Description: | ChEMBL_640752 |
Residue: | 324 |
Sequence: | MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLL
REIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQI
LNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLN
LTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFL
LGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAED
AMKHRYFFNDPLPCDISQLPFNDL
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BDBM5718 |
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n/a |
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Name | BDBM5718 |
Synonyms: | 2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol | 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol | 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine | CHEMBL280074 | Olomoucine | purine deriv. 5 |
Type | Small organic molecule |
Emp. Form. | C15H18N6O |
Mol. Mass. | 298.343 |
SMILES | Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12 |
Structure |
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