| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transporter |
|---|
| Ligand | BDBM50156052 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_303717 (CHEMBL829052) |
|---|
| Ki | 0.680±n/a nM |
|---|
| Citation |  Zhou, J; He, R; Johnson, KM; Ye, Y; Kozikowski, AP Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. J Med Chem47:5821-4 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transporter |
|---|
| Name: | Transporter |
|---|
| Synonyms: | Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66787.87 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1463061 |
|---|
| Residue: | 597 |
|---|
| Sequence: | MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF
YMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLN
LPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI
GLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG
INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN
CVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFL
MLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLT
LLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLL
FVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAY
GITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
|
|
|
|---|
| BDBM50156052 |
|---|
| n/a |
|---|
| Name | BDBM50156052 |
|---|
| Synonyms: | 2-[4-(4-Chloro-phenyl)-1-methyl-piperidin-3-ylmethylsulfanyl]-1-piperidin-1-yl-ethanone | CHEMBL191330 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H29ClN2OS |
|---|
| Mol. Mass. | 380.975 |
|---|
| SMILES | CN1CCC(C(CSCC(=O)N2CCCCC2)C1)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
