| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2E1 |
|---|
| Ligand | BDBM50158911 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_305743 (CHEMBL829415) |
|---|
| IC50 | 31100±n/a nM |
|---|
| Citation |  Denton, TT; Zhang, X; Cashman, JR 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem48:224-39 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2E1 |
|---|
| Name: | Cytochrome P450 2E1 |
|---|
| Synonyms: | CP2E1_HUMAN | CYP2E | CYP2E1 | Cytochrome P450 2E1 (CYP2E1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56860.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05181 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS
|
|
|
|---|
| BDBM50158911 |
|---|
| n/a |
|---|
| Name | BDBM50158911 |
|---|
| Synonyms: | CHEMBL179529 | Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H10N2S |
|---|
| Mol. Mass. | 190.265 |
|---|
| SMILES | CNc1ccc(s1)-c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
