| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50139391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303656 (CHEMBL829004) |
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| Ki | 1.35±n/a nM |
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| Citation |  Cowart, M; Faghih, R; Curtis, MP; Gfesser, GA; Bennani, YL; Black, LA; Pan, L; Marsh, KC; Sullivan, JP; Esbenshade, TA; Fox, GB; Hancock, AA 4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention. J Med Chem48:38-55 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50139391 |
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| n/a |
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| Name | BDBM50139391 |
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| Synonyms: | (R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)benzonitrile | 4-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl}-benzonitrile | ABT-239 | CHEMBL351231 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N2O |
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| Mol. Mass. | 330.4229 |
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| SMILES | C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N |r| |
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| Structure | 
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