| Reaction Details |
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 | Report a problem with these data |
| Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Ligand | BDBM14363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302509 (CHEMBL828224) |
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| Ki | 12000±n/a nM |
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| Citation |  Manallack, DT; Hughes, RA; Thompson, PE The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem48:3449-62 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
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| Type: | Enzyme |
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| Mol. Mass.: | 104751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HCR9 |
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| Residue: | 933 |
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| Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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| BDBM14363 |
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| n/a |
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| Name | BDBM14363 |
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| Synonyms: | 3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one | 5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one | Tocris-0947 | Zaprinast |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N5O2 |
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| Mol. Mass. | 271.2746 |
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| SMILES | CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1 |
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| Structure | 
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