Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAcetylcholine receptor protein alpha/beta/delta/gamma chain
LigandBDBM50166908
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303631
Ki 3540±n/a nM
Citation Coe JWBrooks PRVetelino MGWirtz MCArnold EPHuang JSands SBDavis TILebel LAFox CBShrikhande AHeym JHSchaeffer ERollema HLu YMansbach RSChambers LKRovetti CCSchulz DWTingley FDO'Neill BT Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation. J Med Chem 48:3474-7 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acetylcholine receptor protein alpha/beta/delta/gamma chain
Name:Acetylcholine receptor protein alpha/beta/delta/gamma chain
Synonyms:Acetylcholine receptor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 143080
Components:This complex has 4 components.
Component 1
Name:Acetylcholine receptor
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:56146.98
Organism:Torpedo californica
Description:EBI_19626
Residue:493
Sequence:
MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Acetylcholine receptor
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:58151.68
Organism:Torpedo californica
Description:EBI_19662
Residue:506
Sequence:
MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 3
Name:Acetylcholine receptor
Synonyms:Acetylcholine receptor protein alpha chain
Type:PROTEIN
Mol. Mass.:52735.09
Organism:Torpedo californica
Description:ChEMBL_216981
Residue:461
Sequence:
MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 4
Name:Acetylcholine receptor
Synonyms:Acetylcholine receptor protein delta chain
Type:PROTEIN
Mol. Mass.:59885.01
Organism:Torpedo californica
Description:ChEMBL_142744
Residue:522
Sequence:
MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50166908
n/a
NameBDBM50166908
Synonyms:5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene; dihydrochloride | CHEMBL556954 | VARENICLINE
TypeSmall organic molecule
Emp. Form.C13H13N3
Mol. Mass.211.2624
SMILESC1C2CNCC1c1cc3nccnc3cc21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: