Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor receptor 1

Ligand

BDBM50168469

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303632 (CHEMBL828842)

16±n/a nM

Citation

Dyck, B; Grigoriadis, DE; Gross, RS; Guo, Z; Haddach, M; Marinkovic, D; McCarthy, JR; Moorjani, M; Regan, CF; Saunders, J; Schwaebe, MK; Szabo, T; Williams, JP; Zhang, X; Bozigian, H; Chen, TK Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core. J Med Chem48:4100-10 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor receptor 1

Name:

Corticotropin-releasing factor receptor 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

50744.31

Organism:

Homo sapiens (Human)

Description:

P34998

Residue:

444

Sequence:

MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV

BDBM50168469

n/a

Name

BDBM50168469

Synonyms:

1-(4-Chloro-2,6-dimethyl-phenyl)-5-(1-methoxymethyl-propyl)-7-methyl-1,3,4,5-tetrahydro-1,5,8-triaza-acenaphthylene | CHEMBL372009

Type

Small organic molecule

Emp. Form.

C23H28ClN3O

Mol. Mass.

397.941

SMILES

CCC(COC)N1CCc2cn(-c3c(C)cc(Cl)cc3C)c3nc(C)cc1c23 |(-5.96,4.44,;-4.63,3.66,;-4.63,2.12,;-5.96,1.37,;-7.29,2.14,;-8.62,1.37,;-3.28,1.34,;-1.95,2.11,;-.62,1.34,;-.62,-.21,;.54,-1.24,;-.49,-2.99,;.05,-4.44,;1.56,-4.68,;2.53,-3.5,;2.11,-6.11,;1.13,-7.32,;1.66,-8.75,;-.39,-7.07,;-.93,-5.62,;-2.45,-5.37,;-1.95,-2.53,;-3.28,-3.29,;-4.61,-2.53,;-5.96,-3.31,;-4.61,-.98,;-3.28,-.21,;-1.95,-.98,)|

Structure