| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1/beta-2 |
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| Ligand | BDBM50169959 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304657 (CHEMBL877306) |
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| IC50 | >10000±n/a nM |
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| Citation |  Gaillard, P; Jeanclaude-Etter, I; Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gretener, D; Halazy, S; Nichols, A; Szyndralewiez, C; Vitte, PA; Gotteland, JP Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J Med Chem48:4596-607 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1/beta-2 |
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| Name: | Ribosomal protein S6 kinase beta-1/beta-2 |
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| Synonyms: | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase 1/2 | Ribosomal protein S6 kinase 2/S6K1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 195569 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Ribosomal protein S6 kinase beta-1 |
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| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59139.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | His-tagged S6K1. |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| Component 2 |
| Name: | Ribosomal protein S6 kinase beta-2 |
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| Synonyms: | KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53460.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306115 |
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| Residue: | 482 |
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| Sequence: | MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
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| Component 3 |
| Name: | Ribosomal protein S6 kinase beta-2 |
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| Synonyms: | KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53460.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306115 |
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| Residue: | 482 |
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| Sequence: | MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
GR
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| BDBM50169959 |
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| n/a |
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| Name | BDBM50169959 |
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| Synonyms: | 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile | AS-601245 | AS601245 | CHEMBL1788116 | CHEMBL191384 | [3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N6S |
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| Mol. Mass. | 372.446 |
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| SMILES | N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 |
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| Structure | 
|
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