| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
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| Ligand | BDBM50169965 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304976 (CHEMBL829309) |
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| IC50 | 273±n/a nM |
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| Citation |  Gaillard, P; Jeanclaude-Etter, I; Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gretener, D; Halazy, S; Nichols, A; Szyndralewiez, C; Vitte, PA; Gotteland, JP Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J Med Chem48:4596-607 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 10 |
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| Name: | Mitogen-activated protein kinase 10 |
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| Synonyms: | Jnk3 | MK10_RAT | Mapk10 | Prkm10 | c-Jun N-terminal kinase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52534.34 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1460661 |
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| Residue: | 464 |
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| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSVVKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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| BDBM50169965 |
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| n/a |
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| Name | BDBM50169965 |
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| Synonyms: | CHEMBL363253 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[2-(2-fluoro-phenyl)-ethylamino]-pyrimidin-4-yl}-acetonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16FN5S |
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| Mol. Mass. | 389.449 |
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| SMILES | Fc1ccccc1CCNc1nccc(n1)C(C#N)c1nc2ccccc2s1 |
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| Structure | 
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