| Reaction Details |
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 | Report a problem with these data |
| Target | S-methyl-5'-thioadenosine phosphorylase |
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| Ligand | BDBM50170092 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303908 (CHEMBL828333) |
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| Ki | 0.01±n/a nM |
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| Citation |  Evans, GB; Furneaux, RH; Lenz, DH; Painter, GF; Schramm, VL; Singh, V; Tyler, PC Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem48:4679-89 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| S-methyl-5'-thioadenosine phosphorylase |
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| Name: | S-methyl-5'-thioadenosine phosphorylase |
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| Synonyms: | 5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 31239.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
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| BDBM50170092 |
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| n/a |
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| Name | BDBM50170092 |
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| Synonyms: | 1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-ylmethyl)-4-(4-chloro-phenylsulfanylmethyl)-pyrrolidin-3-ol | CHEMBL365813 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22ClN5OS |
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| Mol. Mass. | 391.918 |
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| SMILES | NC1NC=Nc2c(CN3CC(O)C(CSc4ccc(Cl)cc4)C3)c[nH]c12 |c:3| |
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| Structure | 
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