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TargetNeuronal acetylcholine receptor; alpha2/beta4
LigandBDBM50052593
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304195 (CHEMBL830024)
EC50 3200±n/a nM
Citation Jensen, AAFrølund, BLiljefors, TKrogsgaard-Larsen, P Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem48:4705-45 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor; alpha2/beta4
Name:Neuronal acetylcholine receptor; alpha2/beta4
Synonyms:Neuronal acetylcholine receptor protein alpha-2 subunit/subunit beta-4 | Neuronal acetylcholine receptor subunit alpha-2/beta-4
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 2150172
Components:This complex has 2 components.
Component 1
Name:Neuronal acetylcholine receptor subunit beta-4
Synonyms:ACHB4_HUMAN | CHRNB4 | Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 | Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 | Nicotinic acetylcholine receptor alpha6/alpha3/beta4
Type:Enzyme Catalytic Domain
Mol. Mass.:56388.51
Organism:Homo sapiens (Human)
Description:Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 0 HUMAN::P30926
Residue:498
Sequence:
MRRAPSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQL
SLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNN
ADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTE
IDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLI
IPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLM
FTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAF
PPSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRF
RQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP
PLFQTHAASEGPYAAQRD
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Component 2
Name:Neuronal acetylcholine receptor subunit alpha-2
Synonyms:ACHA2_HUMAN | CHRNA2 | Neuronal acetylcholine receptor; alpha2/beta2
Type:Enzyme Catalytic Domain
Mol. Mass.:59759.69
Organism:Homo sapiens (Human)
Description:Cholinergic, Nicotinic Alpha2Beta2 0 HUMAN::Q15822
Residue:529
Sequence:
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL
RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK
SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY
NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC
ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH
TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE
DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL
RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
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BDBM50052593
n/a
NameBDBM50052593
Synonyms:3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-yl)-pyridine | Altinicline | CHEMBL111659 | US10667515, Compound (S)-SIB 1508Y
TypeSmall organic molecule
Emp. Form.C12H14N2
Mol. Mass.186.253
SMILESCN1CCC[C@H]1c1cncc(c1)C#C
Structure
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