| Reaction Details |
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 | Report a problem with these data |
| Target | C-8 sterol isomerase ERG2 |
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| Ligand | BDBM50170653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303390 (CHEMBL839961) |
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| Ki | >100000±n/a nM |
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| Citation |  Laggner, C; Schieferer, C; Fiechtner, B; Poles, G; Hoffmann, RD; Glossmann, H; Langer, T; Moebius, FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem48:4754-64 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-8 sterol isomerase ERG2 |
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| Name: | C-8 sterol isomerase ERG2 |
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| Synonyms: | C-8 sterol isomerase | Delta-8--delta-7 sterol isomerase | ERG2 | ERG2_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24892.29 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_303390 |
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| Residue: | 222 |
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| Sequence: | MKFFPLLLLIGVVGYIMNVLFTTWLPTNYMFDPKTLNEICNSVISKHNAAEGLSTEDLLQ
DVRDALASHYGDEYINRYVKEEWVFNNAGGAMGQMIILHASVSEYLILFGTAVGTEGHTG
VHFADDYFTILHGTQIAALPYATEAEVYTPGMTHHLKKGYAKQYSMPGGSFALELAQGWI
PCMLPFGFLDTFSSTLDLYTLYRTVYLTARDMGKNLLQNKKF
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| BDBM50170653 |
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| n/a |
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| Name | BDBM50170653 |
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| Synonyms: | (11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 11beta,21-dihydroxypregn-4-ene-3,20-dione | 11beta,21-dihydroxyprogesterone | 17-deoxycortisol | CHEMBL110739 | corticosterone |
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| Type | Small organic molecule |
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| Emp. Form. | C21H30O4 |
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| Mol. Mass. | 346.4605 |
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| SMILES | C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO |r,t:9| |
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| Structure | 
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