Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50170657 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303441 (CHEMBL839610) |
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Ki | 0.60±n/a nM |
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Citation | Laggner, C; Schieferer, C; Fiechtner, B; Poles, G; Hoffmann, RD; Glossmann, H; Langer, T; Moebius, FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem48:4754-64 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50170657 |
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n/a |
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Name | BDBM50170657 |
Synonyms: | 1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine] | 1'-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]; HCl | CHEMBL1788381 | CHEMBL62540 |
Type | Small organic molecule |
Emp. Form. | C18H27N |
Mol. Mass. | 257.4137 |
SMILES | CCCCN1CCC2(CCCc3ccccc23)CC1 |
Structure |
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