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TargetAnti-estrogen binding site (AEBS)
LigandBDBM8885
Substrate/Competitorn/a
Meas. Tech.ChEMBL_303691
Ki>100000±n/a nM
Citation Laggner CSchieferer CFiechtner BPoles GHoffmann RDGlossmann HLanger TMoebius FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem 48:4754-64 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Anti-estrogen binding site (AEBS)
Name:3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase
Synonyms:3-beta-hydroxysteroid-delta(8),delta(7)-isomerase | Cholestenol Delta-isomerase | D8-D7 sterol isomerase | Delta(8)-Delta(7) sterol isomerase | Emopamil-binding protein
Type:PROTEIN
Mol. Mass.:26358.51
Organism:Homo sapiens (Human)
Description:ChEMBL_873432
Residue:230
Sequence:
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
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  Blast E-value cutoff:
BDBM8885
n/a
NameBDBM8885
Synonyms:(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one | 17beta-Hydroxyandrost-4-en-3-one | Testosterone | Testosterone, 1 | US9682960, Testosterone
TypeSteroid
Emp. Form.C19H28O2
Mol. Mass.288.4244
SMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |r,t:18|
Structure
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