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TargetProlyl endopeptidase
LigandBDBM50038879
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306908 (CHEMBL828351)
pH7±n/a
IC50 0.33±n/a nM
Commentsextracted
Citation Jarho, EMWallén, EAChristiaans, JAForsberg, MMVenäläinen, JIMännistö, PTGynther, JPoso, A Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions. J Med Chem48:4772-82 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prolyl endopeptidase
Name:Prolyl endopeptidase
Synonyms:3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme
Type:n/a
Mol. Mass.:80758.04
Organism:Sus scrofa
Description:n/a
Residue:710
Sequence:
MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50038879
n/a
NameBDBM50038879
Synonyms:(S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester | CHEMBL79993 | JTP-4819 | Z-PRO-PROLINAL
TypeSmall organic molecule
Emp. Form.C18H22N2O4
Mol. Mass.330.3783
SMILESO=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r|
Structure
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