Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target5-hydroxytryptamine receptor 6
LigandBDBM50159195
Substrate/Competitorn/a
Meas. Tech.ChEMBL_312893 (CHEMBL827413)
IC50 10.4±n/a nM
Citation Cole, DC; Lennox, WJ; Lombardi, S; Ellingboe, JW; Bernotas, RC; Tawa, GJ; Mazandarani, H; Smith, DL; Zhang, G; Coupet, J; Schechter, LE Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem48:353-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 6
Name:5-hydroxytryptamine receptor 6
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:P50406
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50159195
n/a
NameBDBM50159195
Synonyms:Naphthalene-2-sulfonic acid [3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-amide | Naphthalene-2-sulfonic acid [3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-amide
TypeSmall organic molecule
Emp. Form.C24H25N3O2S
Mol. Mass.419.539
SMILESCN1CCCC1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccc4ccccc4c3)cc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: