Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50159190 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_310551 (CHEMBL834452) |
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EC50 | 2.9±n/a nM |
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Citation | Cole, DC; Lennox, WJ; Lombardi, S; Ellingboe, JW; Bernotas, RC; Tawa, GJ; Mazandarani, H; Smith, DL; Zhang, G; Coupet, J; Schechter, LE Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem48:353-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50159190 |
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n/a |
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Name | BDBM50159190 |
Synonyms: | N-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-4-trifluoromethoxy-benzenesulfonamide | N-[3-((S)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol-5-yl]-4-trifluoromethoxy-benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C21H22F3N3O3S |
Mol. Mass. | 453.478 |
SMILES | CN1CCCC1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)cc12 |
Structure |
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