Reaction Details |
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Target | Endothelin-converting enzyme 1 |
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Ligand | BDBM50159365 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305832 (CHEMBL829574) |
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IC50 | 72.9±n/a nM |
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Citation | Berger, Y; Dehmlow, H; Blum-Kaelin, D; Kitas, EA; Löffler, BM; Aebi, JD; Juillerat-Jeanneret, L Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells. J Med Chem48:483-98 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-converting enzyme 1 |
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Name: | Endothelin-converting enzyme 1 |
Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
Type: | Enzyme |
Mol. Mass.: | 87155.11 |
Organism: | Homo sapiens (Human) |
Description: | P42892 |
Residue: | 770 |
Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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BDBM50159365 |
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n/a |
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Name | BDBM50159365 |
Synonyms: | (3R,5S)-5-{[(2,5-difluorobenzyl)amino]methyl}-1-(5-propylpyrimidin-2-yl)pyrrolidine-3-thiol | CHEMBL194651 |
Type | Small organic molecule |
Emp. Form. | C19H24F2N4S |
Mol. Mass. | 378.482 |
SMILES | CCCc1cnc(nc1)N1C[C@H](S)CC1CNCc1cc(F)ccc1F |
Structure |
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