| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM50159369 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305797 (CHEMBL827985) |
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| IC50 | 20000±n/a nM |
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| Citation |  Berger, Y; Dehmlow, H; Blum-Kaelin, D; Kitas, EA; Löffler, BM; Aebi, JD; Juillerat-Jeanneret, L Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells. J Med Chem48:483-98 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 87155.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42892 |
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| Residue: | 770 |
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| Sequence: | MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
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| BDBM50159369 |
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| n/a |
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| Name | BDBM50159369 |
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| Synonyms: | CGS-31,4447 | CHEMBL415967 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-2-naphthalen-2-yl-ethyl}-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N5O3P |
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| Mol. Mass. | 499.5008 |
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| SMILES | OP(O)(=O)C(Cc1ccc2ccccc2c1)N[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1 |
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| Structure | 
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