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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cannabinoid receptor 2 | ||
| Ligand | BDBM50163123 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303194 (CHEMBL829820) | ||
| Ki | 208±n/a nM | ||
| Citation |  Lange, JH; van Stuivenberg, HH; Coolen, HK; Adolfs, TJ; McCreary, AC; Keizer, HG; Wals, HC; Veerman, W; Borst, AJ; de Looff, W; Verveer, PC; Kruse, CG Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists. J Med Chem48:1823-38 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cannabinoid receptor 2 | |||
| Name: | Cannabinoid receptor 2 | ||
| Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 39690.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34972 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50163123 | |||
| n/a | |||
| Name | BDBM50163123 | ||
| Synonyms: | 2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-5-methyl-1H-imidazole-4-carboxylic acid piperidin-1-ylamide | CHEMBL439657 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H21Cl3N4O | ||
| Mol. Mass. | 463.787 | ||
| SMILES | Cc1c(nc(-c2ccc(Cl)cc2)n1-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |(2.6,-.33,;1.08,-.01,;.47,1.42,;-1.07,1.24,;-1.39,-.26,;-2.75,-.4,;-3.52,-1.76,;-5.06,-1.75,;-5.83,-.4,;-7.37,-.4,;-5.06,.91,;-3.52,.91,;-.06,-1.03,;-.06,-2.57,;1.24,-3.34,;1.24,-4.88,;-.09,-5.63,;-.11,-7.17,;-1.42,-4.86,;-1.39,-3.32,;-2.73,-2.53,;1.24,2.73,;1.17,4.27,;2.71,2.35,;3.8,3.45,;5.3,3.03,;6.38,4.12,;5.98,5.59,;4.49,6.01,;3.39,4.9,)| | ||
| Structure | 
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