Reaction Details |
| Report a problem with these data |
Target | Cannabinoid receptor 1 |
---|
Ligand | BDBM50163122 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_303193 (CHEMBL829819) |
---|
Ki | 30±n/a nM |
---|
Citation | Lange, JH; van Stuivenberg, HH; Coolen, HK; Adolfs, TJ; McCreary, AC; Keizer, HG; Wals, HC; Veerman, W; Borst, AJ; de Looff, W; Verveer, PC; Kruse, CG Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists. J Med Chem48:1823-38 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cannabinoid receptor 1 |
---|
Name: | Cannabinoid receptor 1 |
Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52868.96 |
Organism: | Homo sapiens (Human) |
Description: | P21554 |
Residue: | 472 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
|
|
|
BDBM50163122 |
---|
n/a |
---|
Name | BDBM50163122 |
Synonyms: | 1-(4-Chloro-phenyl)-5-cyano-2-(2,4-dichloro-phenyl)-1H-imidazole-4-carboxylic acid piperidin-1-ylamide | 1-(4-chlorophenyl)-5-cyano-2-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-imidazole-4-carboxamide | CHEMBL369072 |
Type | Small organic molecule |
Emp. Form. | C22H18Cl3N5O |
Mol. Mass. | 474.77 |
SMILES | Clc1ccc(cc1)-n1c(nc(C(=O)NN2CCCCC2)c1C#N)-c1ccc(Cl)cc1Cl |
Structure |
|