Reaction Details |
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Target | Cannabinoid receptor 1 |
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Ligand | BDBM50163114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303193 (CHEMBL829819) |
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Ki | 382±n/a nM |
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Citation | Lange, JH; van Stuivenberg, HH; Coolen, HK; Adolfs, TJ; McCreary, AC; Keizer, HG; Wals, HC; Veerman, W; Borst, AJ; de Looff, W; Verveer, PC; Kruse, CG Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists. J Med Chem48:1823-38 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 1 |
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Name: | Cannabinoid receptor 1 |
Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52868.96 |
Organism: | Homo sapiens (Human) |
Description: | P21554 |
Residue: | 472 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50163114 |
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n/a |
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Name | BDBM50163114 |
Synonyms: | 5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-[1,2,4]triazole-3-carboxylic acid piperidin-1-ylamide; dihydrochloride | CHEMBL558564 |
Type | Small organic molecule |
Emp. Form. | C20H18Cl3N5O |
Mol. Mass. | 450.749 |
SMILES | Clc1ccc(cc1)-c1nc(nn1-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |
Structure |
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