Ki Summary

Reaction Details

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Target

cGMP-specific 3',5'-cyclic phosphodiesterase

Ligand

BDBM50163579

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303177 (CHEMBL829671)

0.29±n/a nM

Citation

Jiang, W; Guan, J; Macielag, MJ; Zhang, S; Qiu, Y; Kraft, P; Bhattacharjee, S; John, TM; Haynes-Johnson, D; Lundeen, S; Sui, Z Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction. J Med Chem48:2126-33 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

cGMP-specific 3',5'-cyclic phosphodiesterase

Name:

cGMP-specific 3',5'-cyclic phosphodiesterase

Synonyms:

PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A

Type:

PROTEIN

Mol. Mass.:

94547.60

Organism:

Rattus norvegicus

Description:

ChEMBL_155367

Residue:

833

Sequence:

MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKIS
ASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSH
LDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIR
LEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVA
QAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFE
EQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREH
DANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKN
KVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT
LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDL
NLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLE
TLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILS
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTA
CDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFID
AICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD

BDBM50163579

n/a

Name

BDBM50163579

Synonyms:

3-Benzo[1,3]dioxol-5-yl-2-(5-pyridin-3-yl-pyrimidin-2-yl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one | CHEMBL355574

Type

Small organic molecule

Emp. Form.

C27H19N5O3

Mol. Mass.

461.4715

SMILES

Oc1c2CN(C(c2nc2ccccc12)c1ccc2OCOc2c1)c1ncc(cn1)-c1cccnc1

Structure