Reaction Details | |||
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Target | Metabotropic glutamate receptor 1 | ||
Ligand | BDBM50163592 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_305883 (CHEMBL874546) | ||
IC50 | 0.550±n/a nM | ||
Citation | Mabire, D; Coupa, S; Adelinet, C; Poncelet, A; Simonnet, Y; Venet, M; Wouters, R; Lesage, AS; Van Beijsterveldt, L; Bischoff, F Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J Med Chem48:2134-53 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 1 | |||
Name: | Metabotropic glutamate receptor 1 | ||
Synonyms: | GPRC1A | GRM1 | GRM1_HUMAN | MGLUR1 | Metabotropic Glutamate 1a | metabotropic glutamate 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 132358.19 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13255 | ||
Residue: | 1194 | ||
Sequence: |
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BDBM50163592 | |||
n/a | |||
Name | BDBM50163592 | ||
Synonyms: | (3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-methoxy-cyclohexyl)-methanone | CHEMBL174588 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23NO3 | ||
Mol. Mass. | 325.4015 | ||
SMILES | CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3OCCCc3cc2c1 |wU:5.8,2.1,(-8.6,-.89,;-7.27,-1.66,;-5.94,-.89,;-5.94,.65,;-4.61,1.42,;-3.28,.65,;-3.28,-.89,;-4.61,-1.66,;-1.95,1.42,;-1.98,2.96,;-.62,.67,;-.62,-.87,;.72,-1.64,;2.05,-.85,;3.39,-1.62,;4.72,-.82,;6.07,-1.57,;7.4,-.8,;7.38,.76,;6.03,1.51,;4.7,.72,;3.36,1.49,;2.04,.69,;.71,1.44,)| | ||
Structure |