Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
Ligand | BDBM50164619 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_303347 (CHEMBL839662) | ||
Ki | 85±n/a nM | ||
Citation | Tatsumi, R; Fujio, M; Satoh, H; Katayama, J; Takanashi, S; Hashimoto, K; Tanaka, H Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. J Med Chem48:2678-86 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-7 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56502.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q05941 | ||
Residue: | 502 | ||
Sequence: |
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BDBM50164619 | |||
n/a | |||
Name | BDBM50164619 | ||
Synonyms: | 5-[(2R)-2'-oxo-3'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazolidin]-3'-yl]thiophene-2-carbonitrile | CHEMBL189370 | ||
Type | Small organic molecule | ||
Emp. Form. | C14H15N3O2S | ||
Mol. Mass. | 289.353 | ||
SMILES | O=C1O[C@@]2(CN1c1ccc(s1)C#N)CN1CCC2CC1 |wU:3.2,(4.73,4.39,;3.79,3.17,;2.25,3.22,;1.71,1.77,;2.95,.82,;4.22,1.7,;5.67,1.18,;6.1,-.29,;7.65,-.34,;8.17,1.11,;6.94,2.06,;9.64,1.54,;11.13,1.98,;1.71,.23,;.38,-.55,;-.94,.23,;-.94,1.77,;.38,2.54,;-.23,1.35,;.87,.72,)| | ||
Structure |