Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-7

Ligand

BDBM50164629

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303347 (CHEMBL839662)

370±n/a nM

Citation

Tatsumi, R; Fujio, M; Satoh, H; Katayama, J; Takanashi, S; Hashimoto, K; Tanaka, H Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. J Med Chem48:2678-86 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuronal acetylcholine receptor subunit alpha-7

Name:

Neuronal acetylcholine receptor subunit alpha-7

Synonyms:

Type:

Enzyme

Mol. Mass.:

56502.44

Organism:

Rattus norvegicus (Rat)

Description:

Q05941

Residue:

502

Sequence:

MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA

BDBM50164629

n/a

Name

BDBM50164629

Synonyms:

(2R)-3'-(1-benzofuran-2-yl)-2'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazolidin]-2'-one | CHEMBL189385

Type

Small organic molecule

Emp. Form.

C17H18N2O3

Mol. Mass.

298.3364

SMILES

O=C1O[C@@]2(CN1c1cc3ccccc3o1)CN1CCC2CC1 |wU:3.2,(2.49,2.31,;1.55,1.09,;.01,1.14,;-.53,-.31,;.7,-1.26,;1.98,-.38,;3.52,-.36,;4.44,-1.6,;5.89,-1.12,;7.24,-1.88,;8.57,-1.09,;8.55,.45,;7.21,1.19,;5.89,.41,;4.43,.88,;-.53,-1.86,;-1.87,-2.63,;-1.37,-1.37,;-2.48,-.73,;-1.87,.46,;-3.19,-.31,;-3.19,-1.86,)|

Structure