| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50164652 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302539 (CHEMBL875215) |
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| Ki | 34±n/a nM |
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| Citation |  Boyle, NA; Rajwanshi, VK; Prhavc, M; Wang, G; Fagan, P; Chen, F; Ewing, GJ; Brooks, JL; Hurd, T; Leeds, JM; Bruice, TW; Cook, PD Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem48:2695-700 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50164652 |
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| n/a |
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| Name | BDBM50164652 |
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| Synonyms: | 2',3'-Dideoxynucleoside5'-alpha-P-Borano-beta,gamma-(difluoromethylene)triphosphates derivative | CHEMBL192192 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15BF2N5O9P3 |
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| Mol. Mass. | 515.007 |
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| SMILES | [BH3-]P(=O)(OCC1CC(C=C1)n1cnc2c1nc(N)[nH]c2=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O |c:8| |
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| Structure | 
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