| Reaction Details |
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 | Report a problem with these data |
| Target | Polyprenyl synthetase family protein |
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| Ligand | BDBM12576 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302625 (CHEMBL839917) |
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| Ki | 17±n/a nM |
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| Citation |  Sanders, JM; Song, Y; Chan, JM; Zhang, Y; Jennings, S; Kosztowski, T; Odeh, S; Flessner, R; Schwerdtfeger, C; Kotsikorou, E; Meints, GA; Gómez, AO; González-Pacanowska, D; Raker, AM; Wang, H; van Beek, ER; Papapoulos, SE; Morita, CT; Oldfield, E Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. J Med Chem48:2957-63 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyprenyl synthetase family protein |
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| Name: | Polyprenyl synthetase family protein |
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| Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41078.35 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_330072 |
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| Residue: | 362 |
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| Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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| BDBM12576 |
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| n/a |
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| Name | BDBM12576 |
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| Synonyms: | Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C7H11NO7P2 |
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| Mol. Mass. | 283.1123 |
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| SMILES | OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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