Reaction Details |
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Target | Polyprenyl synthetase family protein |
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Ligand | BDBM12578 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302625 (CHEMBL839917) |
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Ki | 11±n/a nM |
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Citation | Sanders, JM; Song, Y; Chan, JM; Zhang, Y; Jennings, S; Kosztowski, T; Odeh, S; Flessner, R; Schwerdtfeger, C; Kotsikorou, E; Meints, GA; Gómez, AO; González-Pacanowska, D; Raker, AM; Wang, H; van Beek, ER; Papapoulos, SE; Morita, CT; Oldfield, E Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. J Med Chem48:2957-63 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyprenyl synthetase family protein |
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Name: | Polyprenyl synthetase family protein |
Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
Type: | PROTEIN |
Mol. Mass.: | 41078.35 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | ChEMBL_330072 |
Residue: | 362 |
Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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BDBM12578 |
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n/a |
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Name | BDBM12578 |
Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid |
Type | Small organic molecule |
Emp. Form. | C5H10N2O7P2 |
Mol. Mass. | 272.0896 |
SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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