| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase delta catalytic subunit |
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| Ligand | BDBM50370476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321583 (CHEMBL884691) |
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| pH | 7.5±n/a |
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| IC50 | 2300±n/a nM |
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| Comments | extracted |
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| Citation |  Schnute, ME; Cudahy, MM; Brideau, RJ; Homa, FL; Hopkins, TA; Knechtel, ML; Oien, NL; Pitts, TW; Poorman, RA; Wathen, MW; Wieber, JL 4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases. J Med Chem48:5794-804 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase delta catalytic subunit |
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| Name: | DNA polymerase delta catalytic subunit |
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| Synonyms: | DNA polymerase (alpha/delta/epsilon) | DNA polymerase delta catalytic subunit | DNA polymerase delta subunit 1 | DNA polymerase subunit delta p125 | DPOD1_HUMAN | POLD | POLD1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123636.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105737 |
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| Residue: | 1107 |
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| Sequence: | MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
MRKKVRKDLEDQEQLLRRFGPPGPEAW
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| BDBM50370476 |
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| n/a |
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| Name | BDBM50370476 |
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| Synonyms: | Combivir | ZIDOVUDINE TRIPHOSPHATE |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16N5O13P3 |
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| Mol. Mass. | 507.181 |
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| SMILES | Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO[P@@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| |
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| Structure | 
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