| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-gated cation channel alpha-1 |
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| Ligand | BDBM50172539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320710 (CHEMBL881696) |
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| Kd | 970000±n/a nM |
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| Citation |  Strassmaier, T; Uma, R; Ghatpande, AS; Bandyopadhyay, T; Schaffer, M; Witte, J; McDougal, PG; Brown, RL; Karpen, JW Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies. J Med Chem48:5805-12 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-gated cation channel alpha-1 |
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| Name: | cGMP-gated cation channel alpha-1 |
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| Synonyms: | CNCG | CNCG1 | CNGA1 | CNGA1_BOVIN | cGMP-gated cation channel alpha 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79603.33 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_320711 |
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| Residue: | 690 |
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| Sequence: | MKKVIINTWHSFVNIPNVVGPDVEKEITRMENGACSSFSGDDDDSASMFEESETENPHAR
DSFRSNTHGSGQPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKPDDKNENK
KDPEKKKKKEKDKDKKKKEEKGKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTM
IIARACFDELQSDYLEYWLAFDYLSDVVYLLDMFVRTRTGYLEQGLLVKEERKLIDKYKS
TFQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISN
LVMYIIIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPDFGRLARKYVYSLYWSTLTLTT
IGETPPPVRDSEYFFVVADFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMH
FRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFAD
CEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGS
YFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKGMLEEKGKQI
LMKDGLLDINIANAGSDPKDLEEKVTRMESSVDLLQTRFARILAEYESMQQKLKQRLTKV
EKFLKPLIDTEFSAIEGSGTESGPTDSTQD
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| BDBM50172539 |
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| n/a |
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| Name | BDBM50172539 |
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| Synonyms: | 4-[(4-{[2-(dimethylammonio)ethoxy]carbonyl}phenyl)amino]butan-1-aminium |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27N3O2 |
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| Mol. Mass. | 281.3927 |
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| SMILES | C[NH+](C)CCOC(=O)c1ccc(NCCCC[NH3+])cc1 |
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| Structure | 
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