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TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase
LigandBDBM50173546
Substrate/Competitorn/a
Meas. Tech.ChEMBL_320965 (CHEMBL885372)
Ki 1900±n/a nM
Citation Nguyen, CKasinathan, GLeal-Cortijo, IMusso-Buendia, AKaiser, MBrun, RRuiz-Pérez, LMJohansson, NGGonzález-Pacanowska, DGilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem48:5942-54 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Name:Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:dUTP pyrophosphatase
Type:Protein
Mol. Mass.:19574.43
Organism:Plasmodium falciparum
Description:Q8II92
Residue:173
Sequence:
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
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BDBM50173546
n/a
NameBDBM50173546
Synonyms:1-(5-Trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione | CHEMBL369937 | dUTPase inhibitor, 2
TypeSmall organic molecule
Emp. Form.C28H24N2O4
Mol. Mass.452.5012
SMILESO=c1ccn(C2OC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)C=C2)c(=O)[nH]1 |c:32|
Structure
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