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TargetH(+)-exporting diphosphatase
LigandBDBM12576
Substrate/Competitorn/a
Meas. Tech.ChEMBL_321446 (CHEMBL880254)
IC50 656700±n/a nM
Citation Kotsikorou, ESong, YChan, JMFaelens, STovian, ZBroderick, EBakalara, NDocampo, ROldfield, E Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. J Med Chem48:6128-39 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
H(+)-exporting diphosphatase
Name:H(+)-exporting diphosphatase
Synonyms:Vacuolar-type proton translocating pyrophosphatase 1
Type:PROTEIN
Mol. Mass.:85914.14
Organism:Trypanosoma brucei
Description:ChEMBL_321446
Residue:826
Sequence:
MIKMSPLLLKAAVVTACLCSLAVATTVEEQTAPKPIENATTYQQELGGRGKVDSPTAPGD
AVSITSGIKVMSVTTATAIIFLASAFGFSFAMYWWYVASDIKITPGKGNIMRNAHLTDEV
MRNVYVISKRVSDGANAFLFAEYRYMGIFMLGFGALLYFLLGVAMSSPQGEGKDGRPPVA
VEAPWVNAAFSLYAFVIGAFTSVLAGWIGMRIAVYTNSRTAVMATVGSGGSDNDVLANGS
QSRGYALAFQTAFRGGITMGFALTSIGLFALFCTVKLMQTYFGDSAERLPELFECVAAFG
LGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGM
GSDLFGSFGEATCAALVIAASSAELSADFTCMMYPLLITAGGIFVCIGTALLAATNSGVK
WAEDIEPTLKHQLLVSTIGATVVLVFITAYSLPDAFTVGAVETTKWRAMVCVLCGLWSGL
LIGYSTEYFTSNSYRPVQEIAESCETGAATNIIYGLSLGYISVLPPILAMAFTIYLSHHC
AGLYGYALAALGILSTMSIALTIDAYGPISDNAGGIAEMAHMGHEIREITDALDAAGNTT
AAIGKGFAIGSAAFVALALYGAYVSRVGISTVNLLDARVMAGLLLGAMLPYWFSALTMKS
VGVAAMDMVNEIRRQFQDPAVAAGTKEPDYESCVNIATGAALQQMVAPACLVMLAPIVTG
ILFGRYTLAGLLPGALVSGVQVAISASNTGGAWDNAKKYIEKGGLRDKSKGKGSPQHAAA
VIGDTVGDPLKDTSGPALNILVKLMAIISVVFAPVVQSKLGGLLVK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM12576
n/a
NameBDBM12576
Synonyms:Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
TypeSmall organic molecule
Emp. Form.C7H11NO7P2
Mol. Mass.283.1123
SMILESOC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure
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