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TargetC-C chemokine receptor type 1
LigandBDBM50174716
Substrate/Competitorn/a
Meas. Tech.ChEMBL_325887 (CHEMBL863244)
IC50 800±n/a nM
Citation Revesz, LBollbuck, BBuhl, TEder, JEsser, RFeifel, RHeng, RHiestand, PJachez-Demange, BLoetscher, PSparrer, HSchlapbach, AWaelchli, R Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett15:5160-4 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 1
Name:C-C chemokine receptor type 1
Synonyms:C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:Enzyme
Mol. Mass.:41180.69
Organism:Homo sapiens (Human)
Description:P32246
Residue:355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50174716
n/a
NameBDBM50174716
Synonyms:4-(2-((R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethyl)-7-chloro-6-methoxy-3,4-dihydroquinazolin-2(1H)-one | CHEMBL381223
TypeSmall organic molecule
Emp. Form.C23H26ClFN4O3
Mol. Mass.460.929
SMILESCOc1cc2C(CC(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)NC(=O)Nc2cc1Cl
Structure
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