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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50176709
Substrate/Competitorn/a
Meas. Tech.ChEMBL_327855
Ki 7.9±n/a nM
Citation Starck JPTalaga PQuéré LCollart PChristophe BLo Brutto PJadot SChimmanamada DZanda MWagner AMioskowski CMassingham RGuyaux M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M1 and M3
Synonyms:CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50176709
n/a
NameBDBM50176709
Synonyms:(R)-3-(3-methoxyquinuclidin-3-yl)-1,1-dim-tolylprop-2-yn-1-ol | CHEMBL380583
TypeSmall organic molecule
Emp. Form.C25H29NO2
Mol. Mass.375.5033
SMILESCO[C@@]1(CN2CCC1CC2)C#CC(O)(c1cccc(C)c1)c1cccc(C)c1 |wU:2.1,wD:2.11,THB:1:2:5.6:9.8,(-3.03,-42.39,;-1.54,-42.78,;-1.13,-44.27,;-.93,-45.65,;.6,-44.99,;1.97,-45.62,;1.69,-44.23,;.34,-43.62,;.41,-41.99,;.86,-43.09,;-2.63,-44.67,;-4.12,-45.06,;-5.61,-45.46,;-6.01,-43.97,;-7.11,-45.85,;-7.51,-47.34,;-8.99,-47.75,;-10.09,-46.65,;-9.68,-45.16,;-10.77,-44.07,;-8.2,-44.76,;-5.22,-46.95,;-6.31,-48.03,;-5.91,-49.52,;-4.42,-49.92,;-3.33,-48.83,;-1.84,-49.22,;-3.73,-47.35,)|
Structure
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