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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M2 | ||
| Ligand | BDBM50176722 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_327856 (CHEMBL863986) | ||
| Ki | 20±n/a nM | ||
| Citation |  Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett16:373-7 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M2 | |||
| Name: | Muscarinic acetylcholine receptor M2 | ||
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 | ||
| Type: | GPCR | ||
| Mol. Mass.: | 51730.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08172 | ||
| Residue: | 466 | ||
| Sequence: |
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| BDBM50176722 | |||
| n/a | |||
| Name | BDBM50176722 | ||
| Synonyms: | (R)-1,1-bis(4-fluorophenyl)-3-(3-methoxyquinuclidin-3-yl)prop-2-yn-1-ol | CHEMBL381878 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23F2NO2 | ||
| Mol. Mass. | 383.431 | ||
| SMILES | CO[C@@]1(CN2CCC1CC2)C#CC(O)(c1ccc(F)cc1)c1ccc(F)cc1 |wU:2.1,wD:2.11,THB:1:2:5.6:9.8,(25.27,-13.99,;26.76,-14.38,;27.17,-15.87,;27.37,-17.25,;28.9,-16.59,;30.27,-17.22,;29.99,-15.83,;28.64,-15.23,;28.71,-13.59,;29.15,-14.7,;25.67,-16.27,;24.18,-16.66,;22.69,-17.06,;22.3,-15.57,;21.2,-17.46,;20.11,-16.36,;18.62,-16.76,;18.22,-18.25,;16.73,-18.64,;19.31,-19.34,;20.8,-18.94,;23.09,-18.55,;22,-19.63,;22.39,-21.12,;23.88,-21.52,;24.28,-23.01,;24.97,-20.43,;24.57,-18.95,)| | ||
| Structure | 
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