Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50175763 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_328123 (CHEMBL863930) |
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IC50 | 540±n/a nM |
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Citation | Ban, H; Muraoka, M; Ioriya, K; Ohashi, N Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility. Bioorg Med Chem Lett16:44-8 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
Type: | PROTEIN |
Mol. Mass.: | 64165.56 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_28796 |
Residue: | 545 |
Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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BDBM50175763 |
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n/a |
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Name | BDBM50175763 |
Synonyms: | 1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-2-oxo-4-(3-(3-(piperidin-1-yl)propoxy)phenyl)-1,2-dihydro-1,8-naphthyridin-3-yl)urea dihydrochloride | CHEMBL540370 |
Type | Small organic molecule |
Emp. Form. | C39H52N6O3 |
Mol. Mass. | 652.8686 |
SMILES | CCCCn1c2ncccc2c(-c2cccc(OCCCN3CCCCC3)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O |
Structure |
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