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TargetSterol O-acyltransferase 1
LigandBDBM50175763
Substrate/Competitorn/a
Meas. Tech.ChEMBL_328123 (CHEMBL863930)
IC50 540±n/a nM
Citation Ban, HMuraoka, MIoriya, KOhashi, N Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility. Bioorg Med Chem Lett16:44-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sterol O-acyltransferase 1
Name:Sterol O-acyltransferase 1
Synonyms:ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:PROTEIN
Mol. Mass.:64165.56
Organism:Rattus norvegicus
Description:ChEMBL_28796
Residue:545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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  Blast E-value cutoff:
BDBM50175763
n/a
NameBDBM50175763
Synonyms:1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-2-oxo-4-(3-(3-(piperidin-1-yl)propoxy)phenyl)-1,2-dihydro-1,8-naphthyridin-3-yl)urea dihydrochloride | CHEMBL540370
TypeSmall organic molecule
Emp. Form.C39H52N6O3
Mol. Mass.652.8686
SMILESCCCCn1c2ncccc2c(-c2cccc(OCCCN3CCCCC3)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O
Structure
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