Reaction Details |
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Target | Metabotropic glutamate receptor 8 |
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Ligand | BDBM50007548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_329057 (CHEMBL863306) |
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Ki | 1900±n/a nM |
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Citation | Amori, L; Serpi, M; Marinozzi, M; Costantino, G; Diaz, MG; Hermit, MB; Thomsen, C; Pellicciari, R Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. Bioorg Med Chem Lett16:196-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Metabotropic glutamate receptor 8 |
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Name: | Metabotropic glutamate receptor 8 |
Synonyms: | GRM8_RAT | Gprc1h | Grm8 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 8 (mGlu8) | Mglur8 | glutamate receptor, metabotropic 8 precursor | mGlu8 | metabotropic glutamate 8 |
Type: | Enzyme |
Mol. Mass.: | 101886.18 |
Organism: | Rattus norvegicus (Rat) |
Description: | P70579 |
Residue: | 908 |
Sequence: | MVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINN
KSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
TIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI
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BDBM50007548 |
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n/a |
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Name | BDBM50007548 |
Synonyms: | (S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino-4-phosphonobutanoic acid | 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid | 2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosphono-butyric acid(S-AP4) | 2-amino-4-phosphonobutanoic acid | 2-amino-4-phosphonobutyric acid | CHEMBL33567 | L-(+)-2-amino-4-phosphonobutyric acid | L-1-amino-4-phosphonobutanoic acid | L-AP4 | L-APB |
Type | Small organic molecule |
Emp. Form. | C4H10NO5P |
Mol. Mass. | 183.0997 |
SMILES | N[C@@H](CCP(O)(O)=O)C(O)=O |r| |
Structure |
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